Elimination of a major inhibitor epitope in factor VIII.

FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...

Successful elimination of factor VIII inhibitor using cyclosporin A.

Acquired Factor VIII (FVIII) deficiency is an uncommon but sometimes catastrophic autoimmune condition for which standard immune suppression, such as steroid or immunoglobulin infusion, is often insufficient to induce long-term remission (Dykes et al, 2001). A number of second-line therapies, such as cyclophosphamide, azathioprine and vincristine, have been used with varying success (Morrison &...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran

Acquired factor VIII inhibitor.

PERSISTENT or uncontrolled bleeding is one of the most feared consequences of any surgical procedure. Numerous factors can contribute to its etiology. Among these, both inherited and acquired disorders of coagulation and/or thrombocyte function need to be taken into account. Acquired hemophilia can be caused by antibodies to coagulation factors. Antibodies can arise in hemophilic or nonhemophil...

factor v and viii inhibitor in patients with combined factor v and viii deficiency

patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhib...